I've recently discovered the Adventure Zone podcast and while checking out the Monster of the Week material that is being used in the arc I'm listening to, I noticed it says it's for 2-6 people.
I've never really gotten into playing D&D-esque games like this because my only group of friends that would be interested already have a set roster. However, if it's actually viable for two people, it would be fun to play with my wife!
How good are games like this for just two people? Are there any that are designed for this number or work better than others?