What is your Kryptonite? What game types, game sequences, boss battles or multiplayer types can you just not get to grips with?
Mine is being timed. There was a very short sequence in Uncharted 2 that I just played where ledges retracted under me as I climbed. It drove me into a blind panic. I got there in the end and saved immediately. Quick time events also fall into the timed category as well. Throw up a button symbol that is going to go away in a fraction of a second and I'll forget everything I ever knew about the controller I'm holding.