Neptune's Pride is a browser based real time strategy, set in space. When I say real time, I mean real time, as in small games can take weeks. The basic premise is you share a cluster of stars with other people, and you branch out from the stars you colonize to get other stars, which you can upgrade in various ways. It's sort of like Sins of a Solar Empire meets diplomacy.
http://np.ironhelmet.com/ (free to sign up and play and all that)
http://www.facebook.com/pages/Neptun... Facebook group
You can buy space credits, which allow you to create custom games other people can join. It's worth a try, and if your playing leave your name up here. I might hold a Goodjer server soon.