I have been using the Altec Lansing fx 5051 speakers for about a year now connected via usb.
Have worked fine up until I moved back for christmas break and set things up and now for some reason the Sub audio is routed to the center speaker and the center speaker audio is going to the sub. Don't know why, deleting and then reinstalling drivers did not help.
And it works fine with my soundcard. Should have known.