Random thing you loathe right now.

Seriously good thinking...

Time for anothe batch of things I loathe. Again, thank you for this topic as it allows me to vent a bit

-Spoilers in Youtube videos ranging from movies, shows to games.

-Gaming news baiting headlines ie "Check out the release date" then when you click on it you get the ol "No release date has been released at this time". Fun example of baiting.

-Sitting down with more than one person and one of them not looking at you when speaking but just the other person as if you were invisible.

-BS and politics when it comes to kids sports.

-Parents who don't discipline their kids and let them ruin it for others.

-Contractors who say "sure i can do that too" and yeah, they failed miserably. Stick to your trade if you can't do it!

-While I am on the topic of contractors, those who don't call/reply back.

-Parents who let their kids out in T-shirts and shorts when it's below 20 degrees just to have same kid infect my kid and others, who dress appropriately, with a cold.

-Athletes and celebrities that make tons of money where people who have more important jobs don't.

-Entitled drivers that cut lines of cars at exits.

whispa wrote:

-Parents who let their kids out in T-shirts and shorts when it's below 20 degrees just to have same kid infect my kid and others, who dress appropriately, with a cold.

You, uh... you know colds aren't actually caused by cold weather, right?

hbi2k wrote:
whispa wrote:

-Parents who let their kids out in T-shirts and shorts when it's below 20 degrees just to have same kid infect my kid and others, who dress appropriately, with a cold.

You, uh... you know colds aren't actually caused by cold weather, right?

Uh, yeah but...

https://www.healthline.com/health-ne...

https://www.cnn.com/2022/12/06/healt...

reducing the temperature inside the nose by as little as 9 degrees Fahrenheit (5 degrees Celsius) kills nearly 50% of the billions of virus and bacteria-fighting cells in the nostrils, according to the study published Tuesday in The Journal of Allergy and Clinical Immunology.

“Cold air is associated with increased viral infection because you’ve essentially lost half of your immunity just by that small drop in temperature,”

But cold air can lessen the immune response in the nose, leading to more susceptibility to viruses. Of course, that happens even when properly dressed. (Masks and the like can, however, keep the temps up in your nose and possibly prevent this from happening.)

Immunity means resistance to an infection. But the total amount of immunity and susceptibility isn’t determined solely by what’s in your nose. Even if you have no immunity whatsoever, if you’re not exposed to the causative agent, it’s not a problem.

That is, cold temperatures do not cause infections.

And like, losing HALF your immunity in cold temperature? Nah, fam. Your nose is an external barrier, which wouldn’t even matter if the infection wasn’t airborne to begin with. Your blood is perfectly intact.

Half the immunity normally conferred by the killed-off cells in the *nose*, not in the body, Larry. This is the most recent study (a similar influential one was done in 2015, but I'm not sure if they investigate the same mechanism).

A major goal of this work was to explore whether antiviral activity of EVs is affected by the cold air conditions typical of seasonal environmental fluctuations. In this study, we confirmed an in vivo temperature reduction of approximately 5°C experienced by the nasal cavity in cold ambient environments in healthy human subjects through endoscopically guided measurements. When this nasal temperature reduction was applied to in vitro culture, we determined that cold exposure largely impaired the antiviral activity of TLR3-dependent EVs. In addition, the secretion of EVs and abundance of antiviral miR-17 as well as surface receptor proteins LDLR and ICAM-1 that resulted from TLR3 stimulation were greater at the warm temperature of 37°C relative to those at the cool temperature of 32°C. More importantly, the temperature-dependent antiviral effects of TLR3-stimulated EVs were partially abrogated upon silencing these antiviral components in EVs. The confluence of these observations suggests that the potent antiviral functions mediated by TLR3-dependent EVs are impaired by cold air conditions via a 41.9% decrease in total EV release as well as reduced miRNA packaging (23.8%) and antiviral surface receptor binding activity (24.4% and 77.2%) of individual EV.
Similar to our results, a prior study has reported that the antiviral defense response elicited by rhinovirus infection is temperature dependent.11

Incubating mouse airway cells at the relatively reduced temperature of the nasal cavity during virus replication resulted in lower levels of RIG-I–like receptor, aka RLR, ligand accumulation, impaired RLR function, and decreased IFN responsiveness, leading to less robust antiviral gene expression and restriction of virus. Many respiratory viruses initiate infection in the nasal cavity, which is the first region of contact of inhaled respiratory pathogens and is highly sensitive to changes in ambient air temperature. The diminished innate immune responses to viral infections at cool temperatures could thereby create a more permissive environment for virus replication compared to warm temperatures. These concepts led us to consider the possibility that inhaling cool air in the winter season might impair the antiviral immune defense functions mediated by TLR3-stimulated EVs and decrease resistance to infections by reducing the host cell temperature within the anterior nasal mucosa. Our observations revealed that exposure to cold resulted in increased host susceptibility to respiratory viruses, providing a potential immunologic mechanism for seasonal variation in URIs.

Robear wrote:

Half the immunity normally conferred by the killed-off cells in the *nose*, not in the body, Larry. This is the most recent study (a similar influential one was done in 2015, but I'm not sure if they investigate the same mechanism).

A major goal of this work was to explore whether antiviral activity of EVs is affected by the cold air conditions typical of seasonal environmental fluctuations. In this study, we confirmed an in vivo temperature reduction of approximately 5°C experienced by the nasal cavity in cold ambient environments in healthy human subjects through endoscopically guided measurements. When this nasal temperature reduction was applied to in vitro culture, we determined that cold exposure largely impaired the antiviral activity of TLR3-dependent EVs. In addition, the secretion of EVs and abundance of antiviral miR-17 as well as surface receptor proteins LDLR and ICAM-1 that resulted from TLR3 stimulation were greater at the warm temperature of 37°C relative to those at the cool temperature of 32°C. More importantly, the temperature-dependent antiviral effects of TLR3-stimulated EVs were partially abrogated upon silencing these antiviral components in EVs. The confluence of these observations suggests that the potent antiviral functions mediated by TLR3-dependent EVs are impaired by cold air conditions via a 41.9% decrease in total EV release as well as reduced miRNA packaging (23.8%) and antiviral surface receptor binding activity (24.4% and 77.2%) of individual EV.
Similar to our results, a prior study has reported that the antiviral defense response elicited by rhinovirus infection is temperature dependent.11

Incubating mouse airway cells at the relatively reduced temperature of the nasal cavity during virus replication resulted in lower levels of RIG-I–like receptor, aka RLR, ligand accumulation, impaired RLR function, and decreased IFN responsiveness, leading to less robust antiviral gene expression and restriction of virus. Many respiratory viruses initiate infection in the nasal cavity, which is the first region of contact of inhaled respiratory pathogens and is highly sensitive to changes in ambient air temperature. The diminished innate immune responses to viral infections at cool temperatures could thereby create a more permissive environment for virus replication compared to warm temperatures. These concepts led us to consider the possibility that inhaling cool air in the winter season might impair the antiviral immune defense functions mediated by TLR3-stimulated EVs and decrease resistance to infections by reducing the host cell temperature within the anterior nasal mucosa. Our observations revealed that exposure to cold resulted in increased host susceptibility to respiratory viruses, providing a potential immunologic mechanism for seasonal variation in URIs.

Not. Half.

Even if you could say that some mechanism of anti-viral activity were reduced by half in volume through in-vitro testing related to in-vivo measurements, it is vitally important to emphasize that these are theoretical mechanism-related subjects and lay people shouldn’t be saying nonsense like “This decreases immunity by half.” No. That’s not what the study says.

The only way to say the immunity response and infection prevention (including sub clinical nose infections) would be reduced in half, is if you made a study specifically aiming to measure that variable and you came up with a result specifically saying that. The most this study says is that maybe there is a basis for saying some measure of nasal barrier immunity is compromised by cold weather in some degree, which may suggest a mechanism for increased URIs in cold weather. MAYBE.

This was unintended

Okay, thanks Larry! I appreciate the correction.

I can't figure out which one of you is the "half empty" pessimist?

Fable 2 and 3 not being playable on P.C.

I love 1 but wanted to play the full set again.

So, not only is the Night Court reboot terrible but they f*cked up the theme song. Like, why would you do that?

iaintgotnopants wrote:

So, not only is the Night Court reboot terrible but they f*cked up the theme song. Like, why would you do that?

I like the new theme. But yeah we watched the first 2 and then stopped.

Incidentally John Laroquette son did all the music for the new show

Then his dad could have afforded saxophone lessons.

Intercourse between church and state.

Oh, man, I used to be such a huge fan of Night Court. But for some reason, I just haven't had the chance to check out the new one yet. I'll definitely give it a shot at some point soon, though. More out of curiosity then out of hope. It totally caught me off guard because I didn't even know they were making this one.

It's... They really try, but they should have gone in a different direction I think.

Yeah after Scrubs, Modern Family, and Community, I never need another laugh track ever. You can be exceptionally funny without it so no more of that nonsense.

If it was great wife might put up with it, but it's not, and that was an immediate turnoff.

strangederby wrote:

Fable 2 and 3 not being playable on P.C.

I love 1 but wanted to play the full set again.

3 is playable - there's a hack to remove the Games for Windows Live copy protection which is required, though

I accidentally smashed my little toe into the coffee table really hard, twice. The swelling made for a huge and immensely painful blister after walking the dog. At the time I couldn't tell if the pain was from the toe smashing or the blister, but after the blister burst naturally, the pain relief was both instant and amazing. Like, it still hurt, but only when I touched it. Not a constant stabbing in my foot. Unfortunately, now the blister is coming off my toe, taking almost the whole nail with it in a painful bloody mess.

Which is to say, my foot currently looks like something from a Cronenberg film and my dog is obsessed with trying to lick it whenever he gets the chance.

Eh toenails are overated. I kept getting ingrown nails on my big toe and finally one podiatrist I saw just removed both nails. Been much happier the last decade without them

Stele wrote:

Eh toenails are overated. I kept getting ingrown nails on my big toe and finally one podiatrist I saw just removed both nails. Been much happier the last decade without them

This... this... this is a THING? Must research.

-BEP

Yes. I had both my big toenails removed decades ago after persistent in-growing.

Doesn't have to be the whole nail either. Had only one side of my big toe be a problem. After treatment the nail doesn't grow a cm on the the right. While the rest is normal. Was relatively painless process too.

master0 wrote:

Doesn't have to be the whole nail either. Had only one side of my big toe be a problem. After treatment the nail doesn't grow a cm on the the right. While the rest is normal. Was relatively painless process too.

Yeah that was the first treatment from a different doctor. It didn't hold up and ingrown was back in a couple years.

Maybe just a crappy doctor since this full solution is going 10+ years strong

I had just the side edges trimmed off both of my big toes 30 years ago. Zero problems since. My combat vet step-dad watched the procedure and narrated for me like a nature show while holding my hand.

Had it done on my right big toe about a decade ago, killed the nail bed on the left side of it due to chronic ingrown toenails, and I've never had a problem since. The nerve block injection was the worst pain I've ever been in, though, and that includes flesh-eating bacteria and multiple surgeries taking a chunk of my right shin. Only lasted a few seconds, at least.

Similar.

There is a downside (spoilered for minor grossness), aside from a wonky looking nail.

Spoiler:

it makes the nail more susceptible to fungal infection because now there's a big entryway down the side of your nail for the fungus to get into the nailbed.

I had a quarter of my toe nail removed 30 years ago due to a bad in grown toe nail that got badly infected. Unfortunately it was painful and I passed out in the chair heh. I’m sure nowadays it’s a lot less painful etc.