Well we know what Bethesda had up their sleeve. They just announced a new Fallout game. Fallout 76.
Looks like we're leaving the urban sprawl again, this time heading out into what used to be the countryside. From the music choice, it sounds like we're looking at the Appalachian region of the country. It also sounds like from the trailer it's less of a survival game and more of a "rebuilding society" lean. Interestingly, according to RPS, 2076 "would place the events of this game around two centuries before those of Fallout 3 and 4."
Kotaku article here. Understandably not much right now.
RPS article, suggesting it may be an online game set in Virginia.
Polygon article, emphasizing the gameplay may deprioritize combat a bit.
What's the deal with Vault 76.