Weird Drug Side Effects
Tuesday, August 7th, 2007 - 1:03am
Okay, so I was watching television and an ad for Mirapex (a drug that's supposed to help with restless legs syndrome) came on. Now, I've seen commercials that have drugs with side effects like nausea, diarrhea, etc., but this one has some weird ones. From Wikipedia:
Quote:
Several unusual adverse effects of this medication may include compulsive gambling, hypersexuality, and overeating.
Overeating I can see, but compulsive gambling? And I don't think that second one would be too much of a problem, really - unless you're a nun or a priest.
Any other drugs have weird side effects like these?
"I'm absolutely retarded. Not 100% sure why." - atom
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Seems to simply increase compulsive behavior in general, and those are just the most common manifestations of that.
"PEACE ON EARTH. GOOD WILL TO MEN. PUBLIC SHELTER. ADMISSION 50¢"
Wait, let me get this straight. The medication will cure me of the syndrome and increase the frequency of overeating, gambling away my life, and making sexy time? Where can I sign up for the free trial?
Lag used to be a lot worse back in the day. Hell, it took Jesus 3 days to respawn.
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I think my favorite is birth control. Blood clots. Strokes. Heart Attack. Oh yeah. I'd definitely go for that.
One of the rare side effects of Ambien is hallucinations. When I actually thought my husband was a knight in shining armor, he threw it away for me that evening.
Metronidazole is the worst medication I've ever taken. Headaches were common but what I couldn't get over was the metallic taste I had in my mouth. My tongue also had a white, slimy coating the entire time I was on the drug. No amount of brushing, mouth wash or fluids got rid of it. Disgusting. Just for kicks, serious side effects include seizures and damage of nerves resulting in numbness and tingling of extremities (peripheral neuropathy). AWESOME.
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Oh, here's another thing I love - those meds whose side effects include constipation AND diarrhea. Is it possible to have both at the same time? And what would that be like, I wonder? Maybe it's best left to the imagination...
"I'm absolutely retarded. Not 100% sure why." - atom
"Dhelor + intarwebs = Great ideas." - wordsmythe
"Do I what I do: hate everyone." - Quintin_Stone
Anything with pseudoephedrine/or epinephrine any other andrenaline-boosting agent does terrible and sometimes lasting things to my mind. I avoid them like the plague (Sudafed, common dental injections).
You missed some:
'Furry black tongue'?
There is no way in hell I'm googling that.
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Part of my job when reviewing ER charts is to record side effects of normal drugs so they can be tracked. Given the scope of patients, I'd say side effects are actually pretty rare, except for anything that changes the way your brain works (anti-psychotics, antidepressants, anti-seizure meds, etc). In those cases, the chief complaints can get... interesting.
I was actually on Mirapex for a while. It was originally a Parkinson's medication to help control twitching/jerking, but will also work on some of us with RLS. My problem is that when I'm about to fall asleep, or about to switch sleep cycles (especially when I'm going into REM), I jerk pretty violently which either wakes me up completely, or keeps me from hitting REM. I've left bruises on Crystal, without even waking up. So, I saw a neuro specialist who put me on it.
I didn't take it long enough to see any noticeable difference in my behavior though... because it pretty much made me violently ill. I stopped it, deciding some sleep was better than none. Thankfully it's calmed down a bit... I still twitch when laying down, and I have the occasional muscle spasm in my neck or back during the day, but it's not too bad.
Anti-depressants are easily the drugs with the highest side effects that I see, since putting someone on one is really a crap-shoot anyway. In my own medical history, when I first started getting seen for depression, I was put on Trazadone. I've heard stories of this being a wonder drug, but all I remember was sleeping even more, and trying to drink myself to death a few times (which is completely bizarre, since I can't stand the taste or smell of alcohol, so I really don't drink at all... I just didn't care at the time though). Then came Lexapro, which amplified my mood swings... the ups were WAY UP, and the downs were... disinterested wallowing. Wellbutrin worked well, but I stopped it after a while. I haven't had any problems in years.
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I saw that one too and thought it was a joke at first. I was waiting for the testimonial: "I'm pregnant, have herpes, and owe my bookie 100 grand, but my restless leg syndrome is totally gone."
Been there. Done that. Add gas for the hat trick.
And done without the benefit of meds, all in the "right" combination of foods.
Moo.
That struck me, too. I guess, though, as with seizures and Wellbutrin, they have to hedge their bets against anything that sticks out statistically. In fact, I'll bet ya $100 they don't get a dozen cases of it.
RIP ChronicNecrosis
Wow... that's an easy $100 to make.
The Mayo clinic has found 25 cases of people on Mirapex who became compulsive gamblers on Pramipexole (Mirapex is the brand name). They also found that these people pretty much went back to normal at lower dosages. 11 of these patients were in the 2005 Mayo Clinic report. I've found several references to 14 more being acknowledged since then.
The problem with making that bet, is that this drug has been on the market for a good number of years now, in one incarnation or another. It's been used to treat Parkinson's, cluster headaches, libido issues for people on SSRI's, and a few other things. If this drug were still in clinical trials, it would be hard to prove a significant number of people have had weird side affects, but this one's been treating a large number of people for a while now.
So... when do I get my money?
Edit: In the drug's defense, it's a dopamine agonist, and all of those drugs have a chance to cause compulsive behavior in people. If you gamble here and there, you'll probably get a lot worse on this drug. If you don't gamble at all, you'll become compulsive at doing something else. It won't make you a compulsive gambler if you don't gamble already.
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When I was in Afghanistan in the Army, we were given Anti-Malaria medication. Now that is all well and good because they did a survey of the area and found that some of the mosquitos tested did indeed carry the disease. But one of the side-effects in this drug that they were giving us said, "this medications has been found to cause blindness in lab rats." How could you give a soldier who relies pretty much on all of his senses a drug that may actually cause him to lose an important one.
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wordsmythe - "Jesus would drive a Hummer and burn as much oil as possible, since the dinosaurs it's made out of seem to be confusing people.
I just got done doing a medical study for narcolepsy in which I was given some trial medication from Johnson & Johnson - no idea what it was. I suppose it worked in that I found it impossible to sleep during my daytime sleep tests, but that first night, every hour I would wake up with a feeling of panic, nausea and cold sweats. It just felt like there were people in the room with me. At one point (around 5am) I was sure I could see two ghosts of people in the room. The bitch of it was, because my head was hooked up to a bunch of wires and such I couldn't move more than a foot or two in any direction, so I basically just had to lie there and try not to embarrass myself by freaking out for the sleep tech to see on the night camera.
The inability to stay asleep and the sick feeling upon waking lasted about a week, which sucked, but the hallucinations or whatever that was, thankfully only came around for one more night after that (and then I was home and could get up and walk around). Whatever that med was, though, I definitely want nothing to do with it.
---Todd
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Oily discharge. Best side effect ever.
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Furry black tongue? That's awesome and hilarious.
Oooh, an inhibition inhibitor! Where can I get some and will it add a weird taste when crushed up and added to a beverage?
I love it when one of the possible side effects is "death". Like, "side effects include nausea, headaches, lack of appetite and death." Seems like a bit more than just a side effect, ya know?
Fedaykin98 wrote:
My brother died taking your drug!!! Oh don't worry, it's just a side effect, he'll pop right back up after he stops taking it.
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Something funny I learned in a medications-related training for work, is that all side effects of all participants in a trial have to be listed, regardless of how wacky or unrelated they happen to be. "Impotence" is a common side effect for this reason.
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Since you're all so into it, more info on black furry tongues. Metronidazole is an antibiotic and isn't meant to be taken for more than 14 days. Hell, I was only suppose to take it for 7 days and stopped at day 5 because I wanted to taste food again.
You know what the best thing about antibiotics is? It kills EVERYTHING. The infection and all of your freakin good bacteria. You know what is listed as a possible side effect for antibiotics? [url=http://en.wikipedia.org/wiki/Candida_(genus)]Fungal Infection[/url]. Why? Because all the bacteria you had an allegiance with are DEAD. Candida invaded their lands and were victorious because Amoxicillin can't distinguish between friend or foe. @#$%!
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Damn Candidians. I'll never trust those maple leaf-loving fungal bastards.
Fedaykin98 wrote:
My dad was on something after his bypass surgery that amped his paranoia to exciting new heights. He was sure that people were watching the house and that the mailman was stealing his mail. It should be noted that my dad is a bit of a nutter to begin with.
Red Foxx, standing by.
Well, to be fair to your Dad, I was watching his house and I was reading his mail. I just didn't think he'd see me there in the bushes.
Sorry about the mixup.
Ambien hallucinations made for some real fun roommates in college.
Pepto Bismol and red wine will give you a black tongue, but it brushes off and isn't furry.
As for this restless leg drug, sounds to me like it gets you to release your nervousness in other ways, instead of keeping it in and getting all shakey because of it. I prefer beer and video games, to be honest.
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Levitra claims that one of it's side effects is a rare risk of an erection lasting longer than four hours.
Umm, and how exactly is that a bad thing? Seems to me that if you need to take that type of medication, this will simply give you the opportunity to make up for lost time.
Sounds remarkably similar to a stomach flu or mild food poisoning. Ahh, good times, good times.
LiquidMantis wrote:
I remember watching an ad for E-Trade a few years ago that was a joke ad for a fake medication and some of the side effects included "Projectile vomiting, children born with the head of a Golden Retriever, seeing the dead and bone liquification." The next scene is the guy selling all his stock in the company. I still laugh thinking about it.
"Just because something's popular, that sure doesn't make it right." -Penn Gilette
"You can't fix stupid." -Ron White
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The condition is called priapism. From what I've read from my charts (I see this occasionally, not always with medication side-effects), it apparently feels like your rock hard junk is in a 4-way vice being tightened by a professional wrestler.
In short... DO NOT WANT.
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instant thoughts of Stacy Kielber point to a strong "maybe if...."
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I had a drug reaction that was similar once. The main problem being that I was able to get it up... but the plumbing wouldn't let anything flow during sex no matter how much you wanted it to! Odd part was that about an hour or maybe two after sex I got these odd super-Os that happened wither I wanted them too or not. It was weird as there was no warning at all just hello its time for a big O! I went off that drug because of that and the high blood pressure it also caused. I learned that you do NOT want to go off some drugs as the doctor described it as "rapidly due to rick of heart attack". I got massice head aches that meant I couldn't sleep for about a week and I just wanted to sit there and cry through them. They lasted about a week and I'd classify that week as the worst in my life nearly.
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